Great concept and very fun. A few suggestions to keep the dopamine bowling:

• I’d love to start with a ball so I can start bowling right away!
• Balls can’t be picked up unless you get there after they spawn. This is most obvious when starting a new game, but occurs anytime you camp out by the gutters.
• I keep having to jump between keyboard and mouse. The simplest solution might be to let us click to bowl. Bonus points if we could use the keyboard to select our level up rewards.
• I’d love for more sound effects for whenever we pick up a ball, bowl, and level up. For example, the ball types could have different sounds as they roll and strike pins.

Keep it up!

Very cool idea!  The bowling ball power ups are super neat too~ a magnet ball might be a cool idea (pulls pins back with it).  Keep working on it, it's a fun idea for sure!  Or if you are bored of the bowling concept, you could change it to like a wizard defending a bridge from hordes of enemies while grabbing different spells hehehe. Great job!  Please check out my Hollow Knight inspired metroidvania when you can :D