Please.
Unless you have a very, very good reason to do so. Your game will be removed from all collections it is on. Ratings will not carry over and so on. Even if you use the same url.
Also, you might lose your uploading privileges and or might get delisted, as it can be seen as spamming. It probably is spamming in some cases.
And please think really hard, before you upload a new version as a new project. If you see a need to do that, look again. There are other ways to preserve versions of a game and people expect updates to projects - within the project, not as a new project. And people not following you, but having the game on collection or bookmark will never notice that you "updated". Of course such "updates" can also not be installed by the itch app. And who knows what the app does with deleted games. Probably nothing, since they got deleted. Games are not identified by their url, but by an id.