Yes, for some reason I'm able to start other games without this error from within the Itch.io app. And I'm pretty sure my entire path is ASCII only, so I'll probably feedback to the Itch.io team, then. Thanks for your help!
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There are no special characters in its path. Just to be clear, I installed the game successfully via the Itch.io app, but it fails to start from within the Itch.io app. However, it works if I manually navigate to where the game is installed by Itch.io, and the game starts normally when I double click on the executable. So it sounds like a problem with the Itch.io app?