"my judgement is that as long as its not taking up more paper than the rules permit then its cool if you fold it in a different way. So a trifold or (if you want to get wild) 8 A6 pages is totally cool. I guess you could also do 2 A4 pages if you wanted but that seems boring." https://itch.io/jam/appx-n-jam/topic/5057591/layout-question
Dank Dungeon said that as long as the total area is the same it doesn't matter if it is has a different layout.