Really cool art and aesthetic, and I really like the O2 mechanic and I think it work work very well during play. So after processing this adventure I just have some thoughts about what is going on, and let me know how accurate my comprehension is.
Ophelia was in love with Laertes (who has been assimilated into the Homogen) - So she plays piano for the abomination to lull it to sleep. I assume Ophelia has kind of a weird relationship with the Homogen, as it killed her love, but now her love exists within it. She probably doesn't want to see it harmed or destroyed. I think that creates some interesting tension between Ophelia and the players (and I think perhaps your intention?). But my suggestion is just be a little more explicit about Ophelia's relationship with the Homogen. Also in the security room there is a picture that hints at Ophelia's relationship with Laertes. I would try to include more things the players can find to unravel the story before they meet Ophelia (like a defaced plaque of Dr.Polonius scrated with the words "Justice for Laertes"), more elements of show, don't tell. I would also like to see some instructions on what the Homogen does once it awakes, and a statblock.
Overall a solid adventure filled with horror and melancholy, and something I would love to run :)