Last week, I found this by chance for my own game, thinking "what does it look like when you submit it through virustotal?" Indeed, there was a false positive on the latest version at the time. I went looking for an answer and found that it was due to the packaging and encryption of the game code in the exe. The solution was therefore to separate the game engine from the game data, as indicated, and following this I have not had any new false positives (for now).
(I imagine that some antiviruses must find it suspicious that a portion of an executable is particularly obfuscated or encrypted)