The original Sprytile does not work in Blender 3 or 4. Use ReSprytile instead. That 's een fork of the original and works fine in Blender up to 4.2.
Quick Workaround Fix for Blender 4.4 Crash Paint Tool Resprytile
Replace the following lines (line 184-187 in sprytile_panel.py
right_col.row(align=True).prop(sprytile_data, "paint_align_top", toggle=True, text="")
right_col.row(align=True).prop(sprytile_data, "paint_align_middle", toggle=True, text="")
right_col.row(align=True).prop(sprytile_data, "paint_align_bottom", toggle=True, text="")
right_col.row(align=True).prop(sprytile_data, "paint_hinting")
To this code:
right_col.prop(sprytile_data, "paint_uv_snap", text="Pixel Snap")
right_col.prop(sprytile_data, "paint_stretch_x")
right_col.prop(sprytile_data, "paint_stretch_y")
right_col.prop(sprytile_data, "paint_stretch_z")
In Blender 4.4 enable backface in Sprytile settings (-x,-y painting)
If anyone knows a better solution let it know, because I'm not a developer