It's like that one level in Disc Room where you need to grab pickups around the level to damage the giant disc boss! The modifier stacking and their variety add a lot of challenge and replayability. You can either try to make the game as hard as possible, or try to make it easier, or do a run where you stack a lot of fading jewels... Oh, and the modifiers being negative is an interesting twist, like choosing the best of 3 evils!