As someone who had amoebiasis, although different from amoeba itself, the symptoms shown in the VN is quite accurate. Nausea, vomiting, fever. It has its common grounds with the amoeba. Aside from that, the visuals are appealing yet also disgusting (I meant in a good way.) It really makes the player's stomach churn a little but the colors are not an eye sore, so that is not something to worry about. The writer also did a great job with this. The emotions are raw and there, as if you truly were the one experiencing it. 

Great visual novel overall.