when you say it persists, are you ensuring that you're deleting all Shopsim data from User/Username(Computer name)/appdata/local/shopsim ?

And then also ensuring it is a fresh download in a fresh folder?

These usually play a part in glitches.

For example

when I first downloaded. I loaded up, realized i hadn't deleted my save, Crashed on my first attempt to new game/main menu - deleted shop sim, got new game and worked fairly fine but would still crash if I tried to main menu for any reason aside from the initial boot up.

Later I redownloaded the game because I was worried it was bugged cause I couldn't get the Mastersword Pedestal to work - erased shopsim, erased old game folder, unpacked new game folder and booted it up - Now I can actually go to main menu (at least half the time, sometimes I oddly "freeze" (doesn't acknowledge its frozen/not responding, but is), but this also occurs mostly on boot up, not in-game.

So try a fresh download started up after clearing out the old data.

Also Ensure misc other things are up to date, there can always be an odd one of those causing issue.

Also also Just because nothing else is affected, doesn't mean it can't still be hardware related. - Example. I had a hardware issue some years back that I didn't realize was there - I was able to browse the internet absolutely fine, I was able to watch high quality, and even HD youtube vids, I was able to play many games, with no issue, Many of those games felt to me like they were "hi-tax" games - Good graphics, large demands from hardware, etc - ran just fine.

Plenty of other games though caused a complete system hang (everything turned off except the computer was still technically on, forcing me to have to hold the power button till it turned off all the way, in order to reboot) - and these "plenty" of games almost all felt "low tax" a couple weren't, but many were, it didn't make sense for there to be some kinda power or gfx card issue at fault here, cause they were so low-spec So I replaced my CPU, Nothing. someone suggested maybe it was Mobo, Nope, nothing.

Eventually after talking about the specifics to a few friends and family members - someone finally said that they thought it could actually be Power supply. - and it was.

The Power supply was actually going bad. and Even though I could play plenty of my usual games just fine for hours on end - It was failing to properly run certain games for much more than a few minutes.  After getting it replaced, this was no longer the case. - The First few days I even put it through very torturous experiments, leaving multiple games that caused it to hang running at the same time, mostly just in their main menus, but running, none the less, half of them windowed a couple borderless and a full screen. Nothing went wrong.

But. The point is. That the powersupply was bad, and I still had plenty of games that had no issue, while those few games, did. so never rule out the possibility that you could have a similar issue. - Where seemingly only this game is having trouble, while none of your usual games are.

You can also try using the itch app (or not using it) to see if that changes anything

Equally you can try lowering certain settings, namely the.. last one? I think? controls like grass density or something. - Also should probably ensure the resolution is chosen and not default - and You can use Window too - which helps with taking screenshots - The windowed mode is windowed borderless, I believe, and if its resolution is your desktop resolution, it'll play almost identically to fullscreen.