Excellent game! Loved the aggro mechanics, the autopathing, and lots of other things. Dice could sometimes screw you over, but the bamf mechanic was a great solution to that :D
Shields + poison seems to be the way to go, especially in the lategame. Some minor things I disliked were your crewmembers randomly leaving once they reach a certain skill level, as there's a chance you don't get nice skills back, and near the end it happened to three of my crewmates at the same time just after I leveled up everything, so that felt a bit "meh" :D, and I think the sanity restoration mechanic feels unnecessary. I understand the hardcap, but the drain/restore system feels a bit pointless to me as it's just a matter of a sanctuary pitstop.
Game looks great, audio is nice, gameplay is smooth, the random flavor and banter was neat, and there's not much else to comment on really. Awesome entry, good job :D