Okay, first of all, I like the Game good content. Secondly, Why is the M2F transformation a one time thing, wtf. I though it was a oh its fine I can do that later, until I realised I fucked up over 2hrs of play forcing me to override my save games. Love your game, but don't have that at such a specific place and fucking time, because I started infestation and then got the unwanted cock. WTF.
in my opinion, activate everything in Sanctum to not lose any content, because later in the story you can change the body as you want, either with magic or in a specific location that will be released when you finish a certain part of the story. and as for playing time I have 72 hours total, and I haven't missed any of the story and secrets because of any optional Sanctum options.