So how long is one run through the content at the moment? What kind of time would I have to set back to play through it, once I'm a bit better?
My first complete run clocked in at 70-ish minutes. I was playing carefully, though--switching cards in and out of my deck for a situational advantage of just a few turns then going back to default. Can't imagine it going much longer than that for anyone unless you were really trying to optimize for score (fewest moves).