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Alright, I’ve sorted it out (at least for myself trying to download and play my own game, what a concept).

I had to reexport with this setting enabled:

Then it turns into “You can’t run bcuz maybe malware!” in which case the following command then makes it work:

sudo xattr -rds com.apple.quarantine Escherport.app

So maybe you have an equivalent setting to enable sandbox support?

I've spent a bit trying to find a unity solution but to no success. At least your reuploaded version works for me, it now gives me the option to open after it warns me.

(+1)

I have found however if you download the itch app, the app will run the games for you so you don't have to deal with the apple gatekeeper. I might put that in the download instructions.