It's possible. I've looked at image slicing before but so far haven't found a good workflow for it.
This would help rpgmaker users who use doodad plugins as well, and i would appreciate it. I have already done it for myself for some of the sets
Atlased might work really well!
If you decide to, I'd be incredibly grateful, and more than happy to send you some of the assets I've separated with that program, to save you a tiny bit of time!