Usually when the game is on an external source, or a read only folder, the game gets errors because it can't create save or config files. That could be solved by moving the entire game folder to a different location. However, the error message you get is different, so while this might help, it's probably not going to solve the issue.
Since the error appears randomly and not on specific triggers, and the same error happened for you in other RPG Maker games, it's fair to assume that your system doesn't like such games for some reason. I did google the error message and tried to find a solution, but sadly I saw nothing that applies to your case.
Apart from changing the folder location of the game, what you could also try is to run the game as admin, or run the game on a different device, if you have one. (The save folder on android is hidden however, so transfering the save to or from an android phone doesn't work)
If you play the game on full screen mode, you could try to play it in the normal window resolution to see if that changes something.