Unplayable in Chrome on Android (Samsung phone model).
Opening the second, third, or fourth dropdown menu (Widescreen, Perk notifications, and autosave frequency) immediately closes the menu and snaps you to the top of the scrollbar; and since those are the only ones I tried to use, and tried multiple times at that, I will assume this persists across all menus.
I also would suggest including the button to open settings on the title screen — most people I know prefer to adjudt settings and configurations before they start a new game.