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For me its the opposite issue. The game barely registers my mouse at all and hardly moves no matter what I set my sensitivity to. Overriding the high DPI scaling behavior does nothing to fix this either. I would use the keyboard controls if I could but pressing mouse 1 is the only way to attack so it requires me to reach for my mouse whenever I want to attack which is annoying. 

I'll setup controls for a keyboard only version once the E1M1 jam is over.

It *is* over.

I have the exact same problem.