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Thanks again for this great project!
Would it be possible to have an option to change the sound effects? 
I think that would help add to the flavour and mood of a set of carts. 

This is a good idea but it would defeat the purpose of having all the game data on a pixel image :( I'm aware the sound effects are annoying though, I plan to improve them.

Another approach would be to store the sound effects as WAV files in a 'sfx' folder than Pix64 load at start up. You then are free to put whichever WV file in your local Pix64 'sfx' folder.

I see! I was imagining something like your second approach, being able to replace the sound files in an 'sfx' folder.