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Being a fan of SMT1, another theme that could also help is having one NPC determined to make everyone into Bimbos, while having another determined to undo any bimbo magic done so far, you would interact with these two a bit more, making them the Chaos and Law Heroes respectively. The game series also has a law god and a chaos god, a being in the violet room that turns things into bimbos for you, and another being you could get into contact with to undo bimbo magic.

This is a wonderful idea. Having two NPCs that are aware of the changes due to also being influenced by whatever magical force would be a fun way to have static characters the player can talk to about the magic so things can occur and a story can evolve.