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The potion will be fixed in next patch. For the door I generate 2x keys and 1x chest on each floors which means a player only endanger himself if he opens 2x chests on the same floor and the previosu keys got lost. I'm not sure about what to do about this, any suggestions ?

About the lost keys, I suggest that, if a key disappears and would endanger the floor (more doors + chests than keys), another one should generate.