Hi, I made a website for this purpose. You can apply negative filters for all the stuff that you can also filter on itch.io. Generally speaking my site is always a bit behind itch.io, and I don't have impressions and views data, so my sort options for popularity aren't as good as the ones on itch.io, but for excluding stuff from your results, it does the job.
https://kalrog.itch.io/better-itch-search