Thanks for the in-depth feedback - it really is appreciated and i'm taking it all onboard. Regarding point 1) There is an end, after patient 15 there is a decision point and a resolution, with different options available to you based on trust that you have built with the village through how many patients you successfully treated. However, you are right, it is clear through the feedback i'm getting that the majority of players are not seeing the feedback because it is shown too rapidly. Plus I think it would be useful to show some sort of progression, so that the players knows how many patients are left.
2) I was aware of the text mismatch and thought it might be a nice obfuscation to increase the challenge slightly. Balancing the difficulty of these types of word based comprehension puzzle games is a tricky task. On the other hand I am getting consistent feedback that this might just be interpreted as a mistake rather than intentional.
3) I hear you on the wall of text, colour highlights, player highlights, or underlining are reasonable options. I also intended to mitigate the wall of text with images of the treatments as well visual images of the symptoms. Someone else suggested a table of symptoms and treatments, which while it would organise the information, feels like it would make the puzzle part too easy. Definitely something to think about.