Killer cover art, and I like the title a lot. Good design and keying. I like the map aesthetically, but found it a little hard to identify doors. The bioforge is such a fun idea! I'd like it if all the information was a consolidated and how it works is made more clear. I'd explicitly say it allows you to make pills with the listed bioforge properties. "Will produce product from any combo of chemicals" is pretty vague.
Some other small issues. The ancient myth portion of the intro felt tacked on, and I think it would be even weirder for people who don't know the theme of the jam. I would say you could just remove it entirely.
I think an editing pass to focus on defining terms and clarifying language would really help this one shine. Good job!