Thanks for playing:)
The mouse bounding box was mostly a prototype implementation as I didn't have much time to figure out things. However, I think I would make it so the item automatically centers upon clicking. The items are pretty buggy as it stands, but if it keeps the chaos of the game, I might just leave it. Hopefully...just hopefully I can be in R2.
Combination wise, I think it could vary a lot by method of counting. I had about 2.7 million combinations if I can only use each item once(I think). However, there could be more if I count item reuses... Your comment led to me calculating combinations in a car two days ago, haha.