Things that happened on my latest playthrough, last night:
1) Talked to Esmarai, visited the Blind Eye, engaged a Logothete of Science.
2) Tbg ratntrq gb Wnkbe naq tbg trargvpnyyl grfgrq.
3) Fbyirq gur chmmyr obk naq zrg jvgu Ibfuxbg.
4) Pbzcyrgrq Xebibf'f dhrfg naq yrnearq nobhg Yhzra.
5) Vairfgvtngrq Qentbapra'f qvfnccrnenapr naq pbapyhqrq gung ur snxrq uvf qrngu.
6) Opera.
I'm gonna take a break and pursue some other achievements for a while, such as trying to get assassinated in new and innovative ways.