Could be that it's an event. I guess as soon as you make a decent combo, you need to avoid all events like the plague as you can't decline these effects.
Only 2 things can currently ruin your run - cards turning into a pumpkin(napkin) and a curse decreasing crit by 3, 21->18 so you no longer can play 3 face cards.
You could make a deck consisting of face, and 11 aces though or 21 aces.
21 stone aces, each deals it's value of 16 or more(+5 from relic) to current target when drawn along with all other benefits.