Wow, that is quite a bit of grinding :))
This error is a sanity-check I have added to catch/break possible infinite loops the after your previous bug report.
I will replace it with just a console warning.
Overnight Study + Adapt is an interesting combo, I did not think about it before, although it seems obvious in retrospect.
I really should think of a way to make fatigue more impactful or add some other diminishing-return mechanic.
Upcoming next version will have 'fatigue grows with turn number' ascension option, maybe it is the answer.
> fatigue could also affect regular draw
I hesitated on this before, but just now I've changed fatigue to affect start-of-turn card draw as well. This happens after the fatigue reduction, so you have to accumulate 20+ fatigue to draw 1 less card at the start of turn.
In your example (if played with the new ascension on) it will completely stop card draw at about turn 40, which is I think an acceptable balance point.