This is one that's fine for what it is, but just not my personal cup of tea. I don't mind a vampire story, but if it's in a sci-fi setting, I'd like to see sci-fi twists on the standard tropes. Either the vampire or its enemies using technology in a way you wouldn't see in a classic vampire story, or a science fiction explanation for how someone becomes a vampire, etc. As it is, it feels a bit like you wanted to make an adventure for a different game entirely, but there just happened to be a Mothership Jam going.
The cover art and colour scheme are nice. The vampire is well-characterized. The interior map seems less polished than the rest... I think the gradients on the city, in particular, are what make it feel that way. I'd do away with those.
I like that you weren't afraid to be minimalist, but I think we're a little short of environmental detail in a way that makes things difficult for the Warden. The players will expect more location granularity than "you're in the city" or "you're in the cave," so I'd like to see minimaps for each location. Not necessary with much text to describe the sub-locations, but just a layout with e.g. "Lair," "Pool," "Bone Pit" indicated or whatever. It'd be much easier for the Warden to flesh out the detail from there than improvise the navigational choices on the fly.
Thematically, the vampire's powers are good, but I worry about a couple of them mechanically. Appetite of Terror seems like a lot of bookkeeping for the Warden without much upside in terms of gameplay complexity... tracking stat increases every time the players take stress just for a small % chance of affecting the outcome of her rolls.
More importantly, Bewitchment is going to be unfun for players if they only get a single roll to resist and, on failure, are completely out of the game for a day. Which, for a one-shot, probably means the rest of the scenario. In terms of player agency, it's equivalent to an insta-kill. I'd include rules for how and when a "strong-willed person" (i.e. a player character) can try to break out of the spell, or else allow them to retain control of their character while doing the vampire's bidding, allowing the chance for "malicious compliance" (i.e. doing literally what she asked but not how she expected them to do it).