Based on your info i think you mean Act 3, but as for what you want to know, Gramps is still inaccessible within current content, same with going past the Farm. Lyx is findable, but the process is interesting and i dont remember entirely step by step how. But she is findable. The Nexus also cant be accessed in the current state of the game in Act 3, only attempted to be accessed but fails. I would look forward to the next update which is supposed to be bigger compared to recent updates and move towards continuing the main plot
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Act 1 encompasses everything before you first step into the manor. Act 2 starts there and ends at the church if im remembering right. Then Act 3 goes up till current content. I think one of the update blogs can help with Lyx, im pretty sure i gad to look at it several times to figure out what to do.
Edit: found it. Lyx will appear in Act 3 after you have met Claire in Act 3 and gone to sleep. The event should trigger then, and Lyx becomes available to talk to in the Manor's West Wing