For the most part, it's an isolated thing - save for taking Carla's (bad) advice, or making Sami jealous, there's not a lot of "piss them off to advance the game" stuff. And like the dev said, the beauty of it is that there's always another loop!
Hmm... Thanks guys. I really was just asking as I was confused. There is an option in the settings to take away all the options that would result in a burn. I wish there was a disclaimer there (unless I missed it) that told me I would miss out on paths if I didn't burn them.