The 4.5 release candidate came out a couple days ago: https://godotengine.org/article/release-candidate-godot-4-5-rc-1/

Anyone know if there are any issues with VR support or XR-tools support? While I doubt I'll need any of the new features in 4.5, seems like a good a time as any to try out the bleeding edge.

It's viable :)

Should be fine to use for sure, was kinda hoping it be out in time :)

We are using 4.5 RC1 and so far it's been fine. Haven't ran across any issues using XR tools.