I used The Disco Framework in order to make Hoping This Finds You Well! It helped me to understand NVL mode and how to mechanically craft and implement a textbox which could function as a drag-and-drop item.

Honestly, I felt guilty for NOT using it to make a Disco Elysium-style game; this framework is so mechanically rigorous that I was itching to make something with stats and puzzles and I ended up starting up a new run of Disco Elysium itself. XD

If you're looking for a way to get some robust functionality out of Ren'Py straight out of the box, this framework will show you so many incredible things that you can do. If I wanted to replicate the feeling of not just Disco Elysium, but any TTRPG in a visual novel, this framework is a remarkable foundation.