Do you perhaps forgot to compile the app as an standalone executable in version 0.1.6?
People like me who aren't familiar with renpy programming would have a hard time to use DiskClick with only the script files.
Windows defender is known for making false positives on nearly every program that isn't affiliated with it's own also the code could be considered a little invasive because it uses system information to track stuff so I could see why but I can assure you it's safe if you look in the pyw file source there is nothing malicious going on