When looking for games of a certain tag, it readily seems to offer suggestions for similar tags to add to it, i.e. "Point and click AND Horror." If it doesn't exist yet in some form I'm not seeing, would you consider adding negations, so I could search for games that are Point and click but are not tagged with horror? And similar sorts of constructions.

With so many games, I think people might find more comprehensive search options useful, and it probably wouldn't be too difficult to implement. But perhaps I overlooked something.

This has been a long requested feature: https://github.com/itchio/itch.io/issues/738
Which, very unfortunately, is still not implemented.

I feel like this is one of itch's biggest problems, at the moment, and will probably deter many users.
No matter what kinds of games you like or don't like, as soon as you browse games you'll be plastered with genres you have no interest in. So at the very least, there should be an easy way to exclude genres (and other identifiers if desired) for good.