I have used Quest 2 and now Q3 for >3 years. I've never seen savegame corruption or crashing on start or random/well used/tested apps.

After installing and configuring QGO I had one app fail to start three consecutive times, and when disabling "optimization" it started, but my progress was corrupted, so It started as if it was the first time.

Shortly after I tried another game, again, crashing during loading, then starting w/o "optimizations"  - and luckily it were unharmed.

I have also seen a third app/game crash, but start on second try.   This seems like a crazy unreliable experience, I did not try to use any special settings, just defaults, or even "no profile" for Maloka , which has no profile.

(I did permit the accessibility settings for automatic profile selection)

You should ask the developer for help in their comments section, or by sending them an email if they list a support email. They're unlikely to see your issue here. 

If you want input from the community, I'd recommend you post links to the games you're referring to - there are thousands of games here and many have the same names.