First of all thank you for such an amazing update =)
I humbly think the new windows based UI could use some extra polish. From what was a very unintrusive UI we went to a lot of clicking to open and close/minimize windows. I honestly think this does not marry that well with the simplicity of the game. =)
Overall I would say that I strongly dislike all the UI management that is now part of the game. Somehow I just wish you had made the decision for the player of where to place the UI HUD info elements and make it static. The game (and the game designer) should make that management for the player. Only a much more complicated game (think Civilization) should even consider moving to a player customization UI). As it is now I feel like i'm working in Photoshop instead of playing a simple game =). I hope you don't take this as too harsh, I'm just trying to contribute so you can improve this little gem of a game that I love =)
Here are the changes I would do:
1) Make the hotkeys 1-6 toggle the windows instead of just opening them and flashing them. i.e. when i press 1 and the base info window was already maximized, then close it, if it was closed then open it. (do we really need minimize? I think minimize feature was overkill for this UI I would remove this feature altogether). Thank you so much for implementing this in v1.4.11! It is so much better now. Love that you can also press 2 to cycle through the humans, and then double tap 1 to get rid of the window (because base info window over rides the other which is excellent) This also works when you open a discovery details popup (double tap  to get rid of the popup. Works out great!
2) Add hotkey to close all open UI windows in one go. I suggest the [space] key for this (or some other key that is within reach when you have your hand placed on WASD). Or better yet, make this key a toggle. Meaning when you press it all windows you had open close, and when pressed again they re-open in the same positions.
3) Make the tile info permanent on the bottom right of the screen. (no need for its own UI window, just make it some text like before on top of the world. Striking this one due to good argument put fwd by dev =) 4) The discoveries list was also fine before. I don't see the need to have a separate UI window for it. No it is an extra click to see what the discovery needs to be built. The hover worked fine. I would put it back as a permanent list like before. Striking this one due to good argument put fwd by dev =)
NEW! 5) Make the game remember the positions of the UI windows from one run to the next. Or as an alternative make some sensible default positions for the windows. Like this for example https://imgur.com/a/kO5A0gd
My current game loop is:
Start game > Open wishes, tile info and discoveries windows and place them where I like them > play game to completion > Back to 1 for new game > Reopen and reposition the same windows again > repeat > repeat... it becomes very annoying very quickly
NEW! 6) Maybe make the window and text background in the UI a bit transparent? The current black solid windows are a boot too heavy on the eyes. It would also allow to see what is happening under the windows if needed.
thank you for all the updates!