Blessing a bloodshot eyes drug increases the duration but not the attribute increase. Since the lascivicious coating drug does go from +10 to +15 mdef, the +100% should be a +150% for the sake of internal consistency. Same thing presumably applies to the + variants but blessing drugs seems more of a pure run type of thing.
Blessed blue sugar+ appears to be identical to its non-blessed counterpart. No use case.
With how much time and money it costs to learn blessing I and II, it would be nice if blessed drugs got a buff. For example if they didn't increase addiction past II, or if blessed consumables didn't increase corruption(or if it affected permanent stat changes, but that's probably best left for blessing III)
Somewhat unrelated, but blessing apples when you have 99 blessed apples leaves you with less apples, less mana, and 99 blessed apples. Making it a fancy way to delete apples.