I just downloaded itch.io onto my 2012 macbook pro. I'm also running macos 10.15.7. 

Whenever i open the itch app, it messes with my audio drivers, and makes all input and output devices unavailable. It's very confusing to me, because there are no sound preferences within the itch app itself. I've tried looking but i could not find any threads where anyone had a similar problem. Any fixes please???

I'll add screenshots for context. When itch.io app is open, i am unable to open audio system settings at all. 

Does this happen when you immediately open the app, or when you try to run a game?

I’m not sure why just starting the app could have an impact on your audio devices. We use a platform called ‘Electron’ to build the app in, it’s possible that might be related and could help you when trying to troubleshoot the issue.