As I had conflicts between event handlers of itch.io and my games, I think it would be good to have that option, open the game in a new tab that has no game-specific handlers by it's own, increasing overall compatibility. Frankly, I don't know how you guys get your cursorkeys to work at all.
After I removed itch.io's keydown and keyup handlers via browser dev tools, mine suddently worked - but only until I clicked the page outside of the iframe. Then it didn't work anymore, despite refocusing the iframe. Having such conflicts on a game publishing platform seems kind of odd to me. Easy fix would be a new tab option.