Hmm, i like greatsword too, but it go for more defense than regenerate, so i go try the great axe, the regen is fast but the problem is heal cost :/ and you also need to make your char go for more lower Hp, it kinda risky if this game have boss have big dame skill, in the secondary weapon i am thinking i should go for a little magic because maybe i will meet some monster have some kind of physical dame resistance but on other hand i also want to have a greatsword or sword and shield weapon just maybe i will meet big dame skill from boss. Haizz the more rpg game i played the more thing i need to think when making a build in new rpg game cause idk what the fuk kind of mechanic will happen in new game. Just like Poe the fucking mechanic of it, it is a great game but it soo complex for my tiny brain to understand a fucking 2 hour video explaining basic crafting gear of it
Greataxe is pretty OP. Greatsword has good defense and can still have good regen. You can respec and change weapons ingame, so I wouldn't stress the choice too much. You can also equip 2 weapons and switch between them in battle.
About the only thing you can't change ingame is learning Earth magic since the earth magic trainer isnt ingame yet, but she will be in a month or so.
My general recommendation is just starting with a weapon/element you like, and putting your main damage stat and Vitality on auto-grow so you're guaranteed to do good damage and survive pretty well. Anything beyond that is for when you are more comfortable with builds.