No, there's too much stuff that relies on being in a certain size range and clicking on stuff would be very annoying with the camera zoomed out, so no prestiging to get bigger this time around.
It is more likely we'll have our characters going deeper into the caverns. That, or rebuilding the space ship to be a base of operations where characters can interact or change outfits, even having small conversations too, but we will have to wait until Chubberdy has a clearer vision on how to proceed...
As well as suffer trying to make the saves compatible with each update.
Best of luck to you!