Pretty cool! I've played Battle Network way back in the day, but I haven't really touched the FTL or StS-style games that seem to be the other half of the inspiration. I don't see any issues with the game's central premise, though splitting my attention between picking cards and focusing on positioning in real time was pretty rough on me.
The art was generally nice, but on my second playthrough the game opened with scene with bad guys conversing where all the portraits looked really bad or out of the style.
I played with a keyboard, and I felt like it played just fine.
Bugs I encountered;
After starting a run, the view scrolled so far to the left that the entire map out of view at the start. On my third run it focused on the starting node correctly though
One of the enemies flashed pure white (from damage, or its own attack, I don't remember) and didn't return to normal until I hit it
On picking start a new game after losing a run, the planet selection screen revealed all the planet graphics and focused on the wrong one (Izit and Randar were still labeled "???" in the menu). Also it wouldn't let me select any of the planets.
Not a bug, but seeing a(n unskippable?) trailer and being prompted to go to the store page at the end of every run felt a little aggressive. I'd suggest making the trailer skippable and just put a link to the store page in the main menu screen.