Not sure, the game - if downloaded from Itch - is just using the RenPy engine, which uses the language Python. There's no malware here.
Did it tell you the nature of the virus threat? Some idiots have been uploading a pirated version of Dairy Tale to some sharing sites that does have malware - or at least something in it. The file they uploaded doesn't match what I distribute. So... If you got it 3rd party, it's probably bad. Don't pirate indie games. ;)
In general, Microsoft Defender is really good in the last 5+ years - I recommend that over McAfee. If it's a legit download, your McAfee is probably throwing a false positive.