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For the first one, 3k is a lot but she is weak to aphrodisiacs, and they stack. After a few manticore spikes she gets  500 hp taken away because she's so turned on, which makes it easier.

1. Venefica at full power in her normal form says "Hi" with her 4444 arousal stat.
Remember, this is still a role-playing game, you're going to need to grind a bit… eventually (well, this applies to the average, heard the dev managed to beat her while being severely under-levelled during testing, but keyword: dev).