Do you have any guidance regarding running Locus online via a virtual tabletop like Roll20?
We don't have any Guidance per-sey but there is a Locus module in Roll20 already! You should be able to select it from the dropdown of which game the campaign is for.
You'll have to add the card deck yourself (it's not part of Roll20 modules) but it has character sheets, item cards and automates the dice rolls. Unfortunately the Director will have to have their monsters in another format though as the limitations of Roll20's setup mean we couldn't include them.
Hope that helps and thanks for asking!