I haven't tried it personally, I just have a difficult time getting into most yuri content. I kinda have to be in the mood to give it a shot.
However, I have no issue with you trying out other genres if that's what you wanna do. Despite being an otome, I checked out Rapscallions and ended up really enjoying it-- In part because the MC wasn't super effeminate (I was born female but relate more to men and prefer male pronouns), but the story was just so cute. I was surprised because isekai stories aren't usually my thing.
As for the more serious subject matter, that's also not something that would put me off. I love light hearted games but I thoroughly enjoy more serious dramas and mysteries too. My favorite movie genre is horror.
Like another said, I also generally prefer games with multiple endings, BUT I literally just played a kinetic VN yesterday and enjoyed it.
Since you're explicitly asking for feedback, I will go ahead and play this one to give a more in-depth review.
I don't think you need to worry so much about how your games are received though. The art is charming, the stories are enjoyable, and if you want to make it then you should.