When you get permission (after contacting support) to add formatting to your game page, you can use custom CSS effects.
See https://itch.io/docs/creators/design for more information with the itch side of things.
See https://www.w3schools.com/CSSref/sel_hover.php for how to change CSS styling for when the mouse hovers over the html document element.
Note: It doesn't even need to be <a> links - you can hover over other tags like <p> paragraphs!
Note2: I haven't done this yet with anything that I've made, so I'm not currently able to help with implementing it.