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What to do with the last boss (the hand with a closed eye in it)? I can't damage it or its companions and they can barelly damage me.

For Lowjatar phase 1, you need to disable the accompanying enemies with skills that match them (for example, using Xanthellum on the enemy Xanthellum). After all of them are removed, hitting Lowjatar with anything moves you to the second phase, which is a normal fight.