I currently have a problem :
I'm not able to save at any point in the game when the mod is loaded (both versions have that issue).
Would you mind to check if an input is the cause of this?
Viewing post in Save the Babes for Duke Nukem 3D comments
That's gotta be a back-end problem with eduke32, or a problem with your configuration that is entirely unrelated to my mod, which is really just some basic CON scripting that doesn't even touch the internal components of the game e.g. it uses the basic "ifhitspace" statement to check for player input.
Contact eduke32 support.
I figured out what was the problem.
When you load a custom content directory, EDuke32 will try to create the save file in a folder with the same name as the loaded folder.
So, to solve the issue, you just have to create a folder with the same name as the one you use to load custom content in you EDuke32 folder and the game should start work normally again.